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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are usually characterized by a focus on the practical aspects of research design, like the recruitment process and 프라그마틱 무료 슬롯버프 순위 (https://maps.google.com.qa/url?Q=https://dehn-swain.blogbright.net/will-how-to-check-the-authenticity-of-pragmatic-ever-rule-the-world) consent as well as adherence to the use of commonly available equipment.

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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be valid and lessen the chance of bias is also essential. However excessive heterogeneity could cause problems with the design of the trial.

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The aim of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. Usually, they are commissioned by policymakers and practitioners to guide their decisions. They can also be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used to substitute for explanation trials.

The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace tests for explanations or if they should be an alternative to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study that includes recruitment, design, implementation of the intervention and its follow-up.

There is a growing increase in the number pragmatic trials that have been published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health sciences community is becoming more acquaint to the subject of pragmatics. However, it is important to note that the majority of these trials were conducted in primary care settings.