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Pragmatic trials are trials designed to provide information for the practice of clinical trials in real life. They are often characterized as a focus on the practical aspects of designing a study, including recruitment and consent, adherence and the use of routinely available equipment.

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Pragmatic, a software company, offers a variety of casino games to online gambling platforms. Pragmatic's iGaming solutions are used by the top operators and casinos with a physical location. The company offers front-end design tools, analysis, promotions, marketing and payment systems, as well as security, customer service, and bug reporting. In addition, the company provides its players a secure environment that features high-quality graphics and games.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for pragmatic trials to be reliable and reduce bias in results, is also necessary. A high degree of heterogeneity, however, can cause problems with the trial design.

Pragmatic Play is one of the biggest players on the live casino market offers a variety of classic table games, including Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gaming experience and a wide variety of betting options via virtual. The company also hosts a variety of game shows that make online gambling enjoyable and engaging. Some of these shows feature live hosts, whereas others are hosted by celebrities from the industry.

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Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. Its software is designed to work on mobile devices and supports multiple languages. It has been recognized as one of the leading gaming platforms in the casino industry despite its relatively young age. Wolves is one of the latest games that is a 5-reel slot machine with a healthy RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be a great way to identify the cause-effect relationship between an intervention and its outcomes. However, they should not be used to substitute for explanation trials.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a practical trial which includes the recruitment process, the design and implementation of the intervention, as well as monitoring.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of studies were conducted in primary-care settings.