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Pragmatic trials are studies designed to inform real-world clinical practice. They are usually characterized by a focus on the practical aspects of research design, like recruitment and consent as well as adherence to the use of routinely available equipment.

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Pragmatic is a software developer that offers a broad range of casino games available on online gambling platforms. Pragmatic's iGaming solutions are utilized by the most reputable operators as well as casinos that are located in the land. The company provides front-end design tools, analysis, marketing, promotions payment systems, security, customer service and bug reporting. The company also offers a safe environment with high-quality graphics, gameplay and security.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from various geographical areas. This kind of heterogeneity is essential for practical trials to be valid, and it also helps reduce bias in the results. However too much heterogeneity could lead to problems with the design of the trial.

Pragmatic Play is a major player on the live casino market, offers various classic table games, including Blackjack and Roulette. The company's live studios in Romania and Malta offer a real-life gaming experience for its customers, as well as a full suite of virtual betting options. The company also offers a variety of games which make online gambling fun and interactive. Some of these shows have live hosts, while others are hosted by prominent personalities from the industry.

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The goal of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They also provide a useful way to identify the cause-effect relationship between the intervention and its effects. However, they should not be used in lieu for explanation trials.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study that includes recruitment, design, delivery of the intervention and its follow-up.

There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.