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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described as focusing on practical aspects of design that include the recruitment process and consent, adhering and the use routinely available equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps to reduce bias in the results. However too much heterogeneity could lead to issues with the design of the trial.

Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market offers a variety of classic table games like Blackjack and Roulette. The live studios of the company in Romania and Malta offer customers an authentic experience in gambling as well a full variety of betting options via virtual. The company has also developed numerous interactive game shows that make online gambling fun. Some of these shows have a live host, while others are hosted by famous personalities from the industry.

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Pragmatic Play offers not only mobile-friendly slot machines as well as table games and live casino. Pragmatic Play is licensed and regulated by a variety of governing bodies that include the Malta Gaming Authority and UK Gambling Commission. Its games are backed by top-of-the-line encryption technology, and the company's security team is always available to assist players resolve any issues they might have.

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Legality

Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. Its software is designed to work with mobile devices and supports various languages. It has established itself as one of the leading casino gaming platforms despite its relative infancy. Wolves is one of the most recent releases, a 5-reel slot machine that has a high RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to guide their decision-making. They can also be a great method to determine the cause-effect relationship between an intervention and its outcomes. They should not, however be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the physiological hypothesis or 프라그마틱 슬롯 무료체험 clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study, including recruitment, design, implementation of the intervention, and follow-up.

There is an encouraging increase in the number pragmatic trials published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to note, however, that the majority were conducted in primary-care settings.