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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are usually characterized by a focus on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and participants from different geographic areas. This kind of heterogeneity is necessary for practical trials to be valid and also reduces bias in the results. However, too much heterogeneity could cause issues with the trial design.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They are also a good method of determining the causality between an intervention and its results. They should, however, not be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or 프라그마틱 무료체험 슬롯버프 슬롯체험 (get more info) physiological hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic study, including recruitment, design and delivery of the intervention, as well as monitoring.

There is a positive increase in the number pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.