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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of the research design, like recruitment and consent, adherence, and the use of routinely available equipment.

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A practical trial that employs a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be reliable and reduce bias in results is also essential. However excessive heterogeneity could cause issues with the design of the trial.

Pragmatic Play, a major player on the live casino market offers various classic table games, including Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic gambling experience, as well as a broad range of virtual betting options. The company also offers a variety of game shows which make online gambling exciting and interactive. Some of these shows feature a live host, while others are hosted by prominent personalities from the industry.

Mobile compatibility

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Legality

Pragmatic Play is renowned for its top-notch games, and for offering an exceptional user experience. Its software is designed to work with mobile devices and supports multiple languages. Despite its infancy it has already established itself as a top gaming platform for casinos. The most recent releases include Wolves, a 5-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to simulate real-life scenarios and to achieve maximum validity externally. They are usually ordered by policymakers and practitioners to help inform their decisions. They also provide a useful method to determine the cause-effect relationship between the intervention and its effects. They should, however, not be used to replace the need for explanation studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the elements of a practical trial, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary-care settings.