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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by a focus on the practical aspects of study design, including the recruitment and consent process as well as adherence to the use of commonly available equipment.

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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for practical trials to be valid and also helps reduce bias in the results. However, too much heterogeneity can cause problems with the design of the trial.

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Legality

Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software can be used on mobile devices and in multiple languages. Despite its infancy it has established itself as a premier casino gaming platform. The latest releases include Wolves which is a five-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by policymakers and practitioners to help guide their decisions. They also provide a useful way to identify the cause-effect relationship between the intervention and its effects. However, they should not be used to substitute for the use of explanation trials.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as follow-up.

There is a growing increase in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.