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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on the practical aspects of the research design, like the recruitment and consent process as well as adherence to the use of commonly available equipment.

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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also reduces bias in the results. A high degree of heterogeneity, however can result in problems with the design of the trial.

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Pragmatic Play is known for its top-notch games, and for providing a superior 프라그마틱 슬롯 조작 user experience. Its software is designed to work on mobile devices and supports various languages. Despite its relative youth, it has already established itself as a top gaming platform for casinos. Wolves is one of its latest releases which is a five-reel slot machine with a healthy RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically ordered by policymakers and practitioners to guide their decisions. They are also a good method of determining the causality between the intervention and its effects. However, they shouldn't be used as a substitute for explanatory trials.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made a distinction between explanatory studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic study, including the recruitment process, the design and implementation of the intervention, and monitoring.

There is a growing increase in the number of pragmatic trials published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.